MuXin Li1,
Haifeng Zhao2,
Junhan Hu1,
Le Zhou3,
YongMei Sun4,
Xiaobo Liu1 
For correspondence:- Xiaobo Liu Email: oa1248@163.com
Accepted: 25 August 2018 Published: 30 September 2018
Citation: Li M, Zhao H, Hu J, Zhou L, Sun Y, Liu X. Vitamin B2 enhances development of puberty ovaries via regulation of essential elements and plasma endocrine hormones. Trop J Pharm Res 2018; 17(9):1797-1801 doi: 10.4314/tjpr.v17i9.17
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of vitamin B2 (VB2) on ovarian development during puberty.
Methods: Four groups of domestic hens (Jinghong-1 strain, 12 hens/group) were housed under standard conditions and fed basal diet with or without graded doses of VB2 (10 – 40 mg/kg). At 10 weeks old, 9 hens were sacrificed from each group. Plasma levels of AST, ALT, steroid hormones and growth hormones were determined. In addition, some essential mineral elements in the ovarian tissue of the hens were assayed.
Results: Treatment with VB2 significantly improved ovary and liver organ indices (p < 0.01), but had no deleterious effect on the liver. The different doses of VB2 exerted regulatory effects on homeostasis of essential elements in the ovary (p < 0.01). Moreover, VB2 treatment elevated plasma levels of progesterone (PR) and estrogen (ES), suggesting that it might regulate steroid hormone levels.
Conclusion: These results indicate that VB2 enhances the development of the ovaries during puberty.
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